Triple negative breast cancer preclinical therapeutic management by a cationic ruthenium-based nucleolipid nanosystem

HIGHLIGHTS

SUMMARY

Indeed, for this study, the authors have benefited from using an in_vitro cellular model (MDA-MB-231 cells) on behalf of a definite TNBC phenotype to generate an in_vivo xenograft model of human BCC. Ruthenium Cellular Uptake and Intracellular Biodistribution in MDA-MB-231 Cells Next, cellular uptake of HoThyRu/DOTAP at the IC50 concentration (30 µM, i.e., 9 µM Next, cellular uptake of HoThyRu/DOTAP at the IC50 concentration (30 µM, i.e., of AziRu) was evaluated following in_vitro incubation for 24 h. The analysis via ICP-MS 9 µM of AziRu . . .

 



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