Trkc, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of ewing sarcoma by inhibiting ewsr1-fli1 degradation

HIGHLIGHTS

• who: Min Soo Kim from the Animal studies Animal studies were performed as previously described [54]For tumorigenicity studies, u00d7 , cells suspended in , u03bcl phosphate buffer saline, Matrigel (BD Biosciences) were subcutaneously injected into the left and right hind flank regions of anesthetized mice (, weeks old, n=7). Mice were euthanized at , weeks post-injection, and primary tumors were excised for analysis. For extravasation studies, control-shRNA or TrkC-shRNA cells (, u00d7 , cells) were injected into the tail vein of female BALB/c mice (, weeks old, n=7). After , days, the lungs were excised, fixed in, % formalin . . .
  

   

  

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