HIGHLIGHTS
- who: Valerio Farfariello from the Laboratory Lebanese University of Pathology, NYU Langone Medical Center, New York City, USA have published the Article: TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show how cytosolic and mitochondrial Ca2+ signatures are altered in senescent cells and whether these alterations affect the SASP composition and tumour progression.
SUMMARY
Normal mitochondrial Ca2+ homoeostasis relies on functional endoplasmic_reticulum (ER)-mitochondrial Ca2+ transfer due to constitutive activity of inositol 1,4,5-trisphosphate receptors (IP3R . . .
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