HIGHLIGHTS
- who: Giorgia Chinigu00f2 and collaborators from the Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy have published the Article: TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells, in the Journal: (JOURNAL)
- what: The authors demonstrated that in PCa cells TRPM8 exerts its anti-migratory function through a pore-independent pathway involving the binding to the inactive form of Rap1A and the subsequent inhibition of its activity in promoting cell adhesion. The authors focused on the residues at the interface, central to . . .
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