HIGHLIGHTS
- who: Muhammad Tariq from the (UNIVERSITY) have published the research: Truly “Rational” Polytherapy: Maximizing Efficacy and Minimizing Drug Interactions, Drug Load, and Adverse Effects, in the Journal: (JOURNAL)
- what: The study was not designed to explore synergy between any of the drugs, and drug interaction alone (i.e., higher lamotrigine plasma concentrations mediated by concurrent valproate administration) was an alternative, and more parsimonious explanation, for higher efficacy with a combined valproate-lamotrigine regimen . This study shows that equalizing drug loads between monotherapy and polytherapy regimens may improve patient tolerability of polytherapy and provide a standardized . . .
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