HIGHLIGHTS
SUMMARY
Chronic myeloid leukemia (CML) is a hematological malignancy, of which approximately 90% are caused by BCR-ABL. Tspan32 deficiency increases IL2 secretion and promotes T-cell proliferation, but significantly diminishes the ability to generate pathogen-specific T_cells.18 TSPAN32 expression is significantly reduced in memory T_cells from patients with multiple_sclerosis and in activated B cells and plasma cells in systemic lupus erythematosus patients. When Imatinib was used to treat BCR-ABL and BCR-ABL(T315I) transformed BaF3 cells, the authors found that the expression of Tspan32 was only restored in BCRABL transformed cells, but . . .
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