Tuberous sclerosis complex 1 regulates de2f1 expression during development and cooperates with rbf1 to control proliferation and survival

HIGHLIGHTS

• who: Tuberous Sclerosis Complex and collaborators from the Department of Biology, Developmental Biology Research Initiative, McGill University, Montreal, Canada, Department of Biochemistry and Molecular Genetics have published the paper: Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival, in the Journal: (JOURNAL) of August/19,/2010
• what: The authors report that 1 (TSC1) a well-established tumor suppressor that cell size is an important regulator of dE2F1 during development. The authors demonstrate that tsc1 mutations cooperate with rbf1 mutations to promote both unscheduled S-phase entry . . .
  

   

  

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