Tumor-associated lymphatics upregulate mhc-ii to suppress tumor-infiltrating lymphocytes

HIGHLIGHTS

• who: Claire Y. Li et al. from the Center, New York, NY, USA have published the article: Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes, in the Journal: (JOURNAL) of 30/09/2021
• what: Using murine heterotopic and spontaneous models the authors show that LECs in the TME increase MHC-II expression in the context of increased co-inhibitory signals. The authors provide evidence that in human melanoma and breast cancer also upregulate MHC-II compared to normal tissue Mechanistically the authors show that murine and human dermal LECs can take up . . .
  

   

  

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