HIGHLIGHTS
- who: Thomas R. Flint from the UK Cambridge Institute University of have published the article: Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity, in the Journal: (JOURNAL)
- what: The authors have examined the interactions between cancer, systemic metabolism, and tumor immunology in mice using two cancer types that have been documented to predispose to cachexia, the transplanted C26 model of colorectal cancer (Tanaka et_al, 1990) and the genetically engineered, autochthonous LSL-KrasG12D/+; LSL-Trp53R172H/+; Figure 1. To the cachexia-associated loss of CD3+ T_cells, this analysis demonstrated the depletion of CD8 . . .
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