HIGHLIGHTS
- who: Yan and Juan/Sloan Kettering Institute from the USA Weill Graduate School of Medical Sciences, University have published the paper: Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic therapeutic viruses, in the Journal: (JOURNAL)
- what: The study demonstrated that immunogenic therapeutic viruses could overcome PRC2-loss mediated immune-desert TME and sensitize PRC2-loss tumors to ICBs.
- how: This data indicated that CCL2 expression in the PRC2-wt context required H3K27ac modification at the CCL2 locus and the diminished expression of CCL2 in the . . .
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