HIGHLIGHTS
- who: Francesca Pinci et al. from the Centre National de la Recherche (CNRS), France University of Limoges, France have published the research: Tumor necrosis factor is a necroptosis-associated alarmin, in the Journal: (JOURNAL)
- what: The pro-inflammatory activity of this Thus far the experiments had relied on cell lines to study the relevance and mechanism of necroptosis-induced TNF shedding. The authors focused on this latter phenomenon in the following, since this mechanism likely constitutes the ratelimiting step in mature TNF secretion under these conditions.
- how: These results indicated that necroptosis-driven . . .
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