Tumor-promoting properties of karyopherin β1 in melanoma by stabilizing ras-gtpase-activating protein sh3 domain-binding protein 1

HIGHLIGHTS

• who: Fan Yang from the In vivo tumor growth and pulmonary metastasis assay All the mouse experiments were approved by the Ethics Committee of Shengjing Hospital of China Medical University and followed the National Institutes of Health Guide for the care and use of laboratory animalsBALB/c nude mice aged , weeks were purchased from HFK Biotechnology Co [, ]. Ltd. (Beijing, China). For tumor growth, healthy nude mice were randomly divided into , groups (n=8) named sh-NC, sh KPNB1, sh2-KPNB1, OV-NC, and OV-KPNB1. Cells (, u00d7 , cells) stably overexpressing (SK-, cells) or silencing (, cells) , were subcutaneously . . .
  

   

  

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