Tumor-specific t cell-mediated upregulation of pd-l1 in myelodysplastic syndrome cells does not affect t-cell killing

HIGHLIGHTS

• who: Valentina Ferrari from the New York University, United States have published the paper: Tumor-specific T cell-mediated upregulation of PD-L1 in myelodysplastic syndrome cells does not affect T-cell killing, in the Journal: (JOURNAL)
• what: The authors report that PD-L1 expression on MDS tumor cells is upregulated in the presence of autologous tumor-specific T_cells.

SUMMARY

Personalized therapy by adoptive cell transfer (ACT) of autologous T_cells specific for MDS tumor cell neoantigens is an attractive new approach to treat MDS patients. A potential drawback to this approach . . .

 



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