Tunable microsecond dynamics of an allosteric switch regulate the activity of a aaa+ disaggregation machine

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  • who: Hisham Mazal from the Weizmann Institute University of have published the Article: Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: The authors focus on analysis of the two major dynamic states of the M domain, states 1 and 2, and their relation to various perturbations exerted on ClpB. The authors show that this coupling is exerted through an effect on M-domain dynamics. The authors used FRET efficiency values obtained from three separate donor-acceptor pairs to provide a . . .

     

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