Tunneling nanotube (tnt)-mediated neuron-to neuron transfer of pathological tau protein assemblies

HIGHLIGHTS

• who: Meryem Tardivel from the Inserm UMR-, JPArc, ‘Alzheimer and Tauopathies', Place de Verdun, Lille , France have published the Article: Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies, in the Journal: (JOURNAL)
• what: The authors show that the microtubule-associated a key player in Alzheimer's disease is a bona fide constituent of TNTs. In the present work, using two different cellular models (CAD neuronal cells and rat primary embryonic cortical neurons), the authors demonstrate that extracellular Tau species acts as an extrinsic factor leading to increased formation of TNTs . . .
  

   

  

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