HIGHLIGHTS
SUMMARY
Interestingly, CTNNB1 mRNA expression increased only in sEOC cells, while TWIST1 mRNA levels were increased in both MSFCs and sEOC cells (Fig 1b). When the authors examined the protein expression levels, the authors observed high levels of β-catenin in primary EOC cells, and its expression was reduced in MSFCs and sEOC cells, which was negatively correlated with the protein level of TWIST1 (Fig 1c). Similar to previous reports, the presence of the proteasome inhibitor MG132 blocked TWIST1 degradation in all ovarian cancer cells, primarily in primary EOC cells that did not express TWIST1 (Fig . . .
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