Two epitope regions revealed in the complex of il-17a and anti-il-17a vhh domain

HIGHLIGHTS

  • who: Olga Kostareva and collaborators from the Institute of Protein Research, Russian Academy of Sciences, Institutskaya, , Pushchino, Russia have published the Article: Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A VHH Domain, in the Journal: (JOURNAL)
  • what: The structural analysis of interactions in IL-17A/antibody complexes showed that the solvent-inaccessible H-bonds formed by IL-17A u03b2-turn residues are crucial to epitope-paratope interactions.
  • how: Since the HB0017 has the highest affinity for IL-17A among the known IL-17A-specific antibodies the authors . . .

     

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