Two major genes associated with autoimmune arthritis, ncf1 and fcgr2b, additively protect mice by strengthening t cell tolerance

HIGHLIGHTS

• who: Qijing Li from the The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, China have published the paper: Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance, in the Journal: (JOURNAL)
• what: The authors showed that a mutation of COL2 in mice changing the aspartic acid (D) to a glutamic acid (E) at position 266 (as in humans), allowing a stronger binding to the MHCII molecules, leads to profound T_cell tolerance and decreased susceptibility to arthritis. This study provides a mouse . . .
  

   

  

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