HIGHLIGHTS
- who: Caila A. Pilo and colleagues from the Department of Pharmacology, University of California, San Diego, San Diego, CA, United States, Biomedical Sciences Graduate have published the paper: Two Sides of the Same Coin: Protein Kinase C u03b3 in Cancer and Neurodegeneration, in the Journal: (JOURNAL)
- what: Although defects in autoinhibition generally lead to PKC degradation, this study demonstrated that C1 domain mutations protect PKCu03b3 from phorbol ester-induced downregulation.
SUMMARY
Cancer-associated PKC mutants that impair PKC autoinhibition, including cancer fusion_proteins, are paradoxically loss-of-function because mutant protein is . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.