Type i interferon shapes brain distribution and tropism of tick-borne flavivirus

HIGHLIGHTS

• who: Nunya Chotiwan from the (UNIVERSITY) have published the paper: Type I interferon shapes brain distribution and tropism of tick-borne flavivirus, in the Journal: (JOURNAL) of 25/09/2022
• what: The authors show that type I IFN response specifically limits LGTV replication in ChP and cerebral WM. As the authors show with immunofluorescence that neurons are the main target in WT and microglia and ChP are infected in Ifnar-/-, the detected LGTV reads are likely not contamination from free-floating RNA.
• how: Subsequently the authors evaluated the differentially expressed genes (DEGs) in . . .
  

   

  

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