HIGHLIGHTS
SUMMARY
The scaffold and client model has been initially investigated by building a simple in_vitro model system composed of multivalent polySUMO-polySIM proteins and low valency GFP-SUMO or GFP-SIM proteins. The author will summarize the involvement of aberrant condensates in pathological states such as dysregulated immune_responses and cancer. This has been shown for the cleavage of RNA in_vitro, for the melting of double-stranded nucleic_acids, and for transcription of small nuclear (sn)RNA in_vivo. Phase separation is involved in immune_responses at different levels. Phase separation mediates T-cell receptor (TCR) signal_transduction, a process . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.