HIGHLIGHTS
SUMMARY
Epidemiology, Etiology, Onset, Disease Course Multiple_sclerosis (MS) is a chronic demyelinating disorder of the central nervous system (CNS) characterized at its core by inflammation involving the gray and white matter of the CNS in a multifocal pattern. Pattern I lesions display T_cell and macrophage infiltration, while pattern II lesions show in addition antibody and complement deposition, suggesting a contribution of humoral mechanisms to disease pathology. Relative proportions of B, plasma cells and T_cells also vary. MHC class I molecules (encoded by HLA-A, HLA-B and HLA-C loci), present intracellular self- or non . . .
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