Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl

HIGHLIGHTS

• who: . and collaborators from the Psylo, Australia Ghent University, Belgium have published the research: Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl, in the Journal: (JOURNAL)
• what: The authors first predict the key ligand-binding_sites of MOR via molecular docking simulation, investigate the impact of site mutations on signaling pathways, and finally clarify the signal_transduction mechanism via molecular dynamics (MD) simulation. In all the experiments, a value of p and amp;lt; 0.05 was considered significant and all calculations were performed using GraphPad Prism 8.0 software . . .
  

   

  

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