SUMMARY
The LRRK2 gene encodes a 2527 amino_acid, 286 kDa multi-domain protein from the ROCO family that is characterized by a GTPase Ras-like G domain (Roc) and a C-terminal of the Roc domain (COR). Pathogenic mutations in LRRK2, including the most prevalent, G2019S, are mainly concentrated within the Roc, COR, and kinase domains, resulting in alterations in LRRK2`s biochemical activity. One strategy to identify the genes and pathways influenced by LRRK2-G2019S is to conduct genome-wide mRNA expression profiling to detect changes in gene_expression associated with increased LRRK2 kinase activity. Pallos and colleagues . . .
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