Tyrosine phosphatase activity is restricted by basic charge substituting mutation of substrates

HIGHLIGHTS

• who: Che-Fan Huang from the DepartmentNorthwestern University have published the research: Tyrosine phosphatase activity is restricted by basic charge substituting mutation of substrates, in the Journal: Scientific Reports Scientific Reports
• what: With this approach, the authors found that the u03b2-cat T653K mutant showed significantly (p=0.0120, t-test) more phosphorylation by Src/CA than did WT; T653R mutant also exhibited slightly more phosphorylation than did WT and T653A, consistent with the in_vitro peptide library profiling results (Fig 3e). The work shows that both basic mutants have higher tyrosine phosphorylation levels and lead . . .
  

   

  

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