HIGHLIGHTS
- who: Wenjie Wang and collaborators from the Biomolecular Sciences Institute, Florida International University, Miami, FL, USA have published the article: Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents, in the Journal: (JOURNAL)
- what: This study shows that the variation in TDP1/TOP1 activity ratio in GBM could be a potential predictive biomarker for irinotecan treatment.
- how: To further identify more promising the substrate to yield P12 as the TDP1 reaction product in proportion to an increasing amount of indicators the authors calculated the TDP1 . . .
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