Ube2o targets mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance

HIGHLIGHTS

• who: Yumei Huang from the Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China have published the research: UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance, in the Journal: (JOURNAL)
• what: The authors show that genetical or pharmacological blockade of UBE2O impairs tumor progression and radioresistance in lung cancer in vitro and in vivo and these effects can be restored by Mxi1 inhibition. The authors demonstrate that UBE2O is overexpressed and negatively correlated with Mxi1 protein levels in lung cancer tissues. The work . . .
  

   

  

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