Ubiquitin ligase trim71 suppresses ovarian tumorigenesis by degrading mutant p53

HIGHLIGHTS

• who: Yajie Chen from the Female BALB/c nude mice, weeks old, were purchased from the Department of Laboratory Animal Science in Shanghai Medical College of Fudan UniversityTo evaluate the effect of , overexpression on tumor growth in vivo, mice were subcutaneously inoculated with , × , cells stably expressing pCDH vector or pCDH-, in the left and right flanks, respectively. Inversely, to determine the effect of , depletion on tumor growth, mice were bilaterally inoculated with , × , cells stably expressing Ctrl-Cas, or TRIM Cas, per flank. Tumor growth was monitored every other day with electronic digital calipers in two dimensions. Tumor . . .
  

   

  

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