Ubiquitin-like protein 3 (ubl3) is required for march ubiquitination of major histocompatibility complex class ii and cd86

HIGHLIGHTS

• who: Haiyin Liu from the The University have published the Article: Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors report that UBL3 regulates MARCH1 substrates MHC II and CD86 in an array of mouse and human immune cells, is important for maintaining cDC homeostasis, impacts cDC antigen presentation, and is required for Treg development. This experiment showed the lack of UBL3 did not affect: (i) MHC II-Ii trafficking through the Golgi complex; (ii) proteolytic . . .
  

   

  

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