Ubiquitin proteasome-dependent degradation of the transcriptional coactivator pgc-1α via the n-terminal pathway*

HIGHLIGHTS

• who: Julie Trausch-Azar from the (UNIVERSITY) have published the research work: Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway*, in the Journal: (JOURNAL) of December/17,/2010
• what: As the authors show here using lysine-less mutants of PGC182, PGC182 can be rapidly ubiquitinated and degraded via its N terminus. Third, the authors demonstrate that the C-terminal region(s) of PGC-1␣ are not required for the N-terminal region to be ubiquitinated and DECEMBER 17, 2010.

SUMMARY

PGC-1␣ was identified . . .

 



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