Ubiquitin-specific protease usp2-45 acts as a molecular switch to promote α δ -1-induced downregulation of ca 1.2 channels

HIGHLIGHTS

• who: Abbreviations and colleagues from the Department of Neurosciences, Physiology, and Pharmacology, University College London, London WC E BT, UK have published the article: Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote u03b1 u03b4 -1-induced downregulation of Ca 1.2 channels, in the Journal: (JOURNAL)
• what: The authors show that USP also de-ubiquitylates channels. Using whole-cell current recordings and surface biotinylation assays the authors show that USP2-45 specifically decreases both the amplitude of currents and the amount of subunits inserted at the plasma membrane. The study investigates . . .
  

   

  

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