HIGHLIGHTS
- who: Roland Hjerpe from the Institut University of Glasgow, QQ Glasgow, UK have published the research work: UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome, in the Journal: (JOURNAL) of August/11,/2016
- what: The authors aimed to determine why these parallel delivery mechanisms exist and found that acts with the HSP70-HSP110 disaggregase machinery to clear protein aggregates via the 26S proteasome. recognizes client-bound HSP70 and links it to the proteasome to allow for the degradation of aggregated and misfolded proteins. The authors demonstrate that the UBQLN2/HSP70/26S-proteasome pathway . . .
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