Unburned tobacco smoke affects neuroinflammation-related pathways in the rat mesolimbic system

HIGHLIGHTS

• What: This study investigated the impact of prolonged nicotine exposure via a heat-not-burn (HnB) device on selected genes and signaling proteins involved in inflammatory processes in the rat ventral tegmental area (VTA) and nucleus accumbens (NAc) two brain regions associated with addiction to different drugs including nicotine. In light of the previous results in the prefrontal cortex (PFC), the authors focused this investigation on two other relevant nodes of the mesocorticolimbic reward circuitry represented by VTA and NAc. This study investigated the effects of prolonged nicotine exposure (delivered byThe an present HnB device) the transcriptomic . . .
  

   

  

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