Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

HIGHLIGHTS

• who: Asim Alam and colleagues from the United States University of Nebraska at Kearney have published the research work: Uncoupled nitric oxide synthase activity promotes colorectal cancer progression, in the Journal: (JOURNAL)
• what: This investigation reveals an alternative mechanism in CRC cells.
• how: For this the authors used inhibitors and scavengers of ROS/RNS.
• future: Future studies will need to explore alternative mechanisms of NOS uncoupling including conditions of low as found with elevated expression of arginase or S-glutathionylation of eNOS . Future investigations will involve combining cGMP phosphodiesterase inhibitors and . . .
  

   

  

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