Uncovering regulators of heterochromatin mediated silencing using a zebra fi sh transgenic reporter

HIGHLIGHTS

  • who: NSD et al. from the Department of Genetics, University of Georgia, Athens, GA, United States, Department of Genetics, Development and Cell have published the research work: Uncovering Regulators of Heterochromatin Mediated Silencing Using a Zebra fi sh Transgenic Reporter, in the Journal: (JOURNAL)
  • what: The authors demonstrate that silencing of the concatemeric reporter is dependent on known heterochromatic regulators including the zebrafish SU(VAR)3-9 ortholog, Suv39h1b.
  • how: Given the potential for transcriptional compensation among closely related genes the authors chose to focus on nsd1a/b double mutants for this analysis . . .

     

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