HIGHLIGHTS
- who: EMT-activated secretory and colleagues from the DepartmentThe University of Texas-MD Anderson Cancer Center, Houston, Texas, USA have published the research: underlie vulnerability to PI4K2A antagonism in lung cancer, in the Journal: (JOURNAL)
- what: The authors show that miR-34a regulates PI4KB activity through this mechanism and that ZEB1 silences miR-34a and miR-182/-183 to coordinately inactivate PI4KB and increase PI4K2A levels, thereby executing a PI4KB-toPI4K2A dependency switch that drives lung cancer progression. The authors show that PI4K2A stabilizes AXL and coordinates exocytic and endocytic trafficking of SPP1 and its . . .
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