Understanding in vitro pathways to drug discovery for tdp-43 proteinopathies

HIGHLIGHTS

• who: Hei W. A. Cheng and collaborators from the School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney have published the research: Understanding In Vitro Pathways to Drug Discovery for TDP-43 Proteinopathies, in the Journal: (JOURNAL)
• how: Given this the authors conducted an in-depth characterisation of two different common cellular models of ALS and FTD. Given this the authors investigated whether compound-induced changes to stress granule solubility were associated with increased activity in the ubiquitin-proteasome system. The authors identified differing pathomechanisms in the stress and mutant cellular . . .
  

   

  

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