Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations

HIGHLIGHTS

  • who: Thomas J. Attard and colleagues from the Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, Edinburgh, Edinburgh, United Kingdom have published the Article: Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations, in the Journal: (JOURNAL)
  • what: The authors have first performed a systematic survey of known pathogenic missense mutations across all human tubulins and analysed their positions within the three-dimensional structures of tubulin heterodimers. This approach has allowed the authors to look for patterns in mutations across isotypes, structural locations, and phenotypes, in an . . .

     

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