HIGHLIGHTS
- who: Amanda N. Samuels from the National Institutes of Health (NIH), United States University of Surrey, United Kingdom have published the research: Understanding the contribution of metabolism to Mycobacterium tuberculosis drug tolerance, in the Journal: (JOURNAL) of 31/05/2022
- what: Understanding the mechanisms by which Mtb metabolism impacts tolerance to specific antibiotics, particularly in the host environment, could lead to novel therapeutic approaches.
SUMMARY
Pyrazinamide preferentially accumulates and is maximally active against Mtb in acidified compartments within the macrophage (Santucci et_al, 2021; Santucci et_al, 2022). In unstressed axenic culture conditions . . .
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