Unexpected stability of a prodrug to enzymatic hydrolysis within a hydrated hpmc matrix tablet

HIGHLIGHTS

• who: Sarah Hanley and collaborators from the Drug Product Development, Bristol Myers Squibb, Reeds Lane, Moreton, Merseyside , QW, UK Address: Department of Pharmacy, University of Huddersfield, Queensgate have published the research work: Unexpected Stability of a Prodrug to Enzymatic Hydrolysis within a Hydrated HPMC Matrix Tablet, in the Journal: Pharmaceutics 2022, 14, x FOR PEER REVIEW of 13 demonstrated by the reduced generation of colour from the BCIP/NBT reagent 11within the matrix (Figure 8). Consequently, it is feasible to deliver this phosphate ester prodrug via a hydrophilic matrix tablet, despite the uptake of various ALP concentrations . . .
  

   

  

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