HIGHLIGHTS
SUMMARY
Metastasis is the spread of cancer cells from the primary point of appearance to surrounding tissues and to distant organs. Early prediction contributes to reducing the metastatic expansion of cancerous cells through targeting strategies. Tissues` 2 of 19 morphological factors and biomechanical properties have been used to identify metastatic cancers, and to some extent, they achieve their goal. Histological, cytological, and biomarker-based analysis provide an assessment of the cancer stage, as well of the clinical variables which are used for prognostic insights, whose stratification risk value, however, is insufficient for predicting survival outcomes . . .
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