HIGHLIGHTS
- who: Birmingham and colleagues from the University of have published the research work: University of Birmingham, in the Journal: (JOURNAL) of April/18,/2018
- what: The authors propose that the beneficial effects of GCs may be enhanced through combination with reagents targeting specific microRNAs. mice (NR3C1 in humans).
SUMMARY
Sep. Cro MINIREVIEW Author's Choice Prolonged GC exposure can cause adverse effects. Among mRNAs whose expression significantly increased following Dicer knockdown were CYP11A1, CYP11B1, and CYP17A1, which encode cytochrome oxidase enzymes involved in cortisol biosynthesis or interconversion between aldosterone and cortisol . . .
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