HIGHLIGHTS
- who: KO R S M and colleagues from the Rockefeller University for Sick Children, Paris, France have published the research work: Unlocking life-threatening COVID-19 through two types of inborn errors of type IFNs, in the Journal: (JOURNAL)
SUMMARY
This condition is the most clinically severe inborn error of type I IFN immunity, with much more serious consequences than AR partial STAT1 deficiency, which has been reported in eight other patients. The selective impairment of downstream ISGF3-dependent type I and III IFN responses, with intact GAF-dependent type I, II, and . . .
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