Unravelling the pharmacokinetics of aflatoxin b1: in vitro determination of michaelis-menten constants, intrinsic clearance and the metabolic contribution of cyp1a2 and cyp3a4 in pooled human liver microsomes

HIGHLIGHTS

• who: Orphélie Lootens and Marthe De Boevre from the University of Bologna, Italy have published the paper: Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis-Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes, in the Journal: (JOURNAL)
• what: Number of donors in HLM pool Substrate 535*CYP3A4 Reference 583*CYP1A2 *CLH,u,int for CYP3A4 and CYP1A2 based on the contribution determined via the inhibition assay.
• how: The obtained results are shown in Figures 1A-C. The former published data . . .
  

   

  

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