HIGHLIGHTS
- who: Sebastian Adam from the (UNIVERSITY) have published the research work: Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis, in the Journal: (JOURNAL) of 13/Dec/2021
- what: The authors demonstrate that four proteins, CgnB, CgnC, CgnD and CgnE, are sufficient to produce the core scaffold of 1 and 2 in_vitro and propose a biosynthetic scheme for 1 and 2. The authors propose the following biosynthetic scheme for crocagins (Fig 5b): After expression of CgnA, the precursor peptide is processed by the proteins CgnB, CgnC and CgnE and undergoes hydroxylation at the . . .
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