Unveiling a family of spiro- -lactams with anti-hiv and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates

HIGHLIGHTS

• who: u03b2-Lactams and collaborators from the Monash University, Australia have published the research work: Unveiling a family of spiro- -lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates, in the Journal: (JOURNAL)
• what: Altogether, this work comprises a successful strategy of rational structure modulation and optimization of a lead molecule, allowing the identification of new twenty-two highly bioactive spirocyclopentene-u03b2-lactams, three of which display improved antimicrobial activity against HIV and/or Plasmodium when compared to BSS-730A.
• how: The results . . .
  

   

  

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