Unveiling sex-based differences in parkinson`s disease: a comprehensive meta-analysis of transcriptomic studies

HIGHLIGHTS

  • who: Adolfo Lu00f3pez-Cerdu00e1n from the , Valencia, Spain have published the research: Unveiling sex-based differences in Parkinson`s disease: a comprehensive meta-analysis of transcriptomic studies, in the Journal: (JOURNAL)
  • what: Our in silico approach has highlighted sexbased differential mechanisms in typical PD hallmarks (inflammation, mitochondrial dysfunction, and oxidative stress).
  • how: The authors explored the biological implications of the SN meta-analysis results by applying 3 different functional profiling methods over-representation analysis (ORA) the generation of protein-protein interactions (PPI) networks and the transcription factors activity analysis (Fig 1). The authors . . .

     

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