Upregulated ca2+ release from the endoplasmic reticulum leads to impaired presynaptic function in familial alzheimer’s disease

HIGHLIGHTS

• who: Temitope Adeoye and collaborators from the Department of Neurobiology and Behavior, University of California, Irvine, CA, USA have published the research: Upregulated Ca2+ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimeru2019s Disease, in the Journal: Cells 2022, 2167 of /2022/
• what: The work provides direct evidence in support of a crucial role played by altered Ca2+ homeostasis mediated by intracellular stores in FAD. The work provides novel insights on the pathologic role of aberrant neuronal Ca2+ handling on glutamate release and the downstream effects on synaptic dysfunction and cognitive . . .
  

   

  

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