Upregulated dual oxidase 1-induced oxidative stress and caspase-1-dependent pyroptosis reflect the etiologies of heart failure

HIGHLIGHTS

• What: This study was designed to evaluate the potential role of DUOX1 in Materials and methods AC16 cells were treated with 2 µmol/L of doxorubicin (DOX) for 12 24 and 48 h to construct a model. In line with these previous reports, the data in this study showed the increased caspase-1 expression when the level of pyroptosis was high. This study showed the increased secretion of IL-1β and IL-18 when DUOX1 was overexpressed in AC16 cells, suggesting that the caspase-1-dependent pyroptosis in heart failure was triggered by the upregulation of DUOX1 . . .
  

   

  

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