Upregulated endonuclease regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes

HIGHLIGHTS

• who: Jeong-In Yang from the School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea have published the paper: Upregulated endonuclease Regnase-1 suppresses osteoarthritis by forming a negative feedback loop of catabolic signaling in chondrocytes, in the Journal: (JOURNAL)
• what: The authors demonstrate that upregulated Regnase-1 in OA chondrocytes protects against posttraumatic OA cartilage destruction by modulating the expression levels of matrix-degrading enzymes.
• how: The results are consistent with the idea that upregulated Regnase-1 in OA chondrocytes has chondro-protective effects in DMM-induced . . .
  

   

  

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